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Extra info for Alchohol Distillation Principles Equipment Relationships and Safety
We became interested in adenosine because adenosine production in the kidney significantly increases very early following ischemic hypoxia . There is a primary oxygen-sensing reaction which may be triggered by secondary biochemical changes such as a decrease in cellular ATP, increase in ADP and AMP, and stimulation of adenosine and hypoxanthine production . This metabolic pathway for adenosine production during hypoxia is shown in Fig. 6. There are two independent routes for the production of extracellular adenosine.
Proc Nat! Acad Sci USA 87:4139-4143 8. Li Jp, D'Andrea AD, Lodish HF, Baltimore D (1990) Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature 343:762-764 9. Ikawa Y, Aida M; Inoue Y (1976) Isolation and characterization of high and low differentiation-inducible Friend leukemia lines. Gan 67:767-770 10. Sasaki R, Yanagawa SI, Hitomi K, Chiba H (1987) Characterization of erythropoietin receptor of murine erythroid cells.
We hypothesize that, as a' consequence of Epo-R overexpression, a large amount of Epo-R protein is present in the endoplasmic reticulum and able to interact in turn with gp55 Env protein. Thus SFFV can playa role in the oncogenic transformation of these cells both by LTR insertional activation of the Epo-R and by gp55 association with this receptor. Acknowledgements. We acknowledge Jennifer Richardson for critical reading of the manuscript. References 1. Ruscetti S, Wolff L (1984) Spleen focus forming virus: relationship of an altered envelope gene to the development of a rapid erythroleukemia.